領域:生物與新醫藥
職稱級別:教授,高級
博士后(The Scripps Research Institute)
研究興趣:
基于有機小分子的疾病關聯細胞器變化分析與功能調控,糖探針調控炎癥反應與腫瘤免疫識別(有機、化學生物學專業招生)
近期主要代表論著:
1.Responsive hetero-organelle partition conferred fluorogenic sensing of mitochondrial depolarization; Zhongwei Xue, Hu Zhao, Jian Liu, Jiahuai Han, Shoufa Han*, Chem. Sci. 2017, 8, 1915-1921
2.Imaging lysosomal pH alteration in stressed cells with a sensitive ratiometric fluorescence sensor, Zhongwei Xue, Hu Zhao, Jian Liu, aJiahuai Han, Shoufa Han*, ACS Sensors. 2017, 2, 436-442
3.Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface, Bijuan Lin, Xuanjun Wu, Hu Zhao, Yunpeng Tian, Jian Liu, Jiahuai Han, and Shoufa Han*, Chem. Sci. 2016, 7, 3737-3741
4.A carbohydrate-grafted nanovesicle for fluorescence and acoustic imaging of tumors, Xuanjun Wu, Bijuan Lin, Mingzhu Yu, Jiahuai Han, Shoufa Han*, Chem. Sci. 2015, 6, 2002-2009
5.A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation; Xuanjun Wu, Mingzhu Yu, Bijuan Lin, Hongjie Xing, Jiahuai Han, and Shoufa Han*, Chem. Sci. 2015, 6, 798-803
6.Optical Tracking of Phagocytosis with an Activatable Profluorophore Metabolically Incorporated into Bacterial Peptidoglycan; Yunpeng Tian, Mingzu Yu, Zhu Li, Jiahuai Han, Liu Yang*, Shoufa Han*, Anal. Chem., 2015, 87, 8381-8386
7.Lysosomal pH Decrease in Inflammatory Cells Used To Enable Activatable Imaging of Inflammation with a Sialic Acid Conjugated Profluorophore; Mingzhu Yu, Xuanjun Wu, Bijuan Lin, Jiahuai Han, Liu Yang, and Shoufa Han*, Anal. Chem., 2015, 87, 6688-6695
8.A self-referenced nanodosimeter for reaction based ratiometric detection of hypochlorous acid in living cells,Xuanjun Wu, Zhu Li, Yuhui Yang, Liu Yang, Jiahuai Han and Shoufa Han* Chem. Sci., 2013, 460-467
9.Rhodamine-deoxylactam functionalized poly[styrene-alter-(maleic acid)] as lysosome activatable probes for intraoperative detection of tumors,Zhu Li, Yunlong Song, Yuhui Yang, Liu Yang, Xiaohong Huang, Jiahuai Han and Shoufa Han*, Chem. Sci., 2012, 2, 2941-2948
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