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姚宏

領域:生物與新醫藥

職稱級別:教授,高級

    近年來,在抗腫瘤藥物的高通量篩選、中藥質量控制及體內過程研究、藥品的質量控制等方面開展了大量研究工作。2014年入選福建省高等學校新世紀優秀人才支持計劃,2015年入選福建省衛生系統中青年骨干人才。主持國家自然科學基金項目2項和?。ú浚┘壙蒲姓n題十余項。先后主持國家自然科學基金青年項目、面上項目各1項和?。ú浚┘壙蒲姓n題多項。近年來在Sensor Actuat B-Chem、Int J Nanomed、Drug Metab Rev、J Mol Med、Phytomed、Food Chem等SCI期刊上發表學術論文近60篇,獲國家授權專利6項。2015年獲福建省醫學科技獎三等獎(1/5),2012年獲陜西省科學技術一等獎(6/10),2011年獲陜西高等學??茖W技術獎一等獎(6/10),2010年獲“陳可冀中西醫結合發展基金”資助項目首屆優秀論文二等獎,2007及2009年獲福建省自然科學優秀學術論文三等獎等獎項。

    近一年發表研究論文舉要:

    1. Peiying Shi; ...;  Yao, Hong (通訊作者). Non-covalent modification of glassy carbon electrode with isoorientin and application to alpha-fetoprotein detection by fabricating an immunosensor. Sensors & Actuators: B. Chemical, 2020, 305, 127494.

    2. Yao, Wensong; ...; Yao, Hong (通訊作者之一); et al. Delicaflavone induces ROS-mediated apoptosis and inhibits PI3K/AKT/ mTOR and Ras/MEK/Erk signaling pathways in colorectal cancer cells. Biochemical Pharmacology, 2020, 171, 113680.

    3. Chen, Bing; ...; Yao, Hong (通訊作者之一); et al. Improved solubility, dissolution rate, and oral bioavailability of main biflavonoids from Selaginella doederleinii extract by amorphous solid dispersion. Drug Delivery, 2020, 27, 309-322.

    4. Yao, Wensong; ...; Yao, Hong (通訊作者之一); et al. Delicaflavone induces apoptosis via mitochondrial pathway accompanying G2/M cycle arrest and inhibition of MAPK signaling cascades in cervical cancer HeLa cells. Phytomedicine, 2019, 62, 152973.

    5. Chen, Bing; ...; Yao, Hong (通訊作者之一); et al. Proliposomes for oral delivery of total biflavonoids extract from Selaginella doederleinii: formulation development, optimization, and in vitro–in vivo characterization. International Journal of Nanomedicine, 2019, 14, 6691-6706.

    6. Li, Shaoguang; ...; Yao, Hong (通訊作者之一); et al. Protective effects of five compounds from Livistona chinensis R. Brown leaves against hypoxia/ reoxygenation, H2O2, or adriamycin-induced injury in H9c2 cells. Drug Design, Development and Therapy, 2019, 13, 1555-1566.

    7. Huang, Xuliang ; ... ; Yao, Hong (通訊作者之一); et al. Simultaneous Determination of Five Irdoid Glycosides and Three Flavonoid Glycosides in Hedyotis Diffusa Wild by UPLC-UV with Ultrasound-Assisted Extraction. Current Pharmaceutical Analysis, 2019, 15, 808-818.

    8.Xie, Yuanjiao; ... ; Yao, Hong (通訊作者之一); et al. Qualitative and Quantitative Analysis of the Major Ingredients of a Herbal Preparation, Ciwujia Injection by Combination of HPLC-Q-TOF-MS, HPLC-TQ-MS/MS and UPLC-PDA. Current Pharmaceutical Analysis, 2019, 15, 388-398.

    9. Huang, Jianyong; ... ; Yao, Hong (通訊作者之一); et al. An integrated pharmacokinetic study of Dengzhanxixin injection in rats by combination of multicomponent pharmacokinetics and antimyocardial ischemic assay. RSC Adv., 2019, 9, 25309.

    10. Peiying Shi; ...;  Yao, Hong (通訊作者). Simultaneous Determination of Five Phenolic Acids and Four Flavonoid Glycosides in Rat Plasma Using HPLC-MS/MS and Its Application to a Pharmacokinetic Study after a Single Intravenous Administration of Kudiezi Injection. Molecules, 2019, 24, 64

    基金項目舉要:

    1. 國家自然科學基金面上項目:基于“分而治之”融合“效應加權”策略的冠心丹參方多成分整合藥動學新方法研究,55萬,81973558,2020/01-2023/12。(在研,主持人)

    2. 福建省科技創新聯合資金項目:天然抗癌活性小分子Delicaflavone的抗肺癌作用機制、靶標及代謝特征研究,40萬元,2017Y9123,2017.12-2020.12。(在研,主持人)

    3. 國家自然科學基金青年基金項目:冠心丹參方藥代動力學標志性成分的擇取研究,23萬,81202987,2013/01-2015/12。(結題,主持人)

    4. 福建省自然科學基金面上項目:三種民間抗癌中草藥的藥效物質高效篩選及便于其質控的二維碼建立研究,4萬元,2016J01371,2016.04-2019.03。(結題,主持人)

    學術兼職:

    福建省藥學會第七屆中藥和天然產物專業委員會委員


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